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Dixon CA began work, which would reveal how somatic histones are replaced by protamines in a regular series of biochemical changes Strikingly, the mutants that were attenuated in virulence also had a decreased ability to grow in the presence of various stress conditions potentially encountered in an infection process. This enzyme recognizes and removes pyrimidine dimers Mizuno JP were the first to isolate the antifungal antibiotic polyoxin.

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